Fungal Infections

February 26, 2012

How to Identify the Various Types of Yeast Infections

How to Identify the Various Types of Yeast Infections

February 14, 2012

BY 

Candida albicans is a type of bacterial fungus that is present in every one of us in various areas of the body. When an imbalance occurs in the body causing the so-called bad bacteria to grow, this enables the fungus to grow and thrive resulting in a yeast infection. A yeast infection can occur in numerous areas of the body and each area can have various symptoms. These symptoms may sometimes be difficult to diagnose because they are similar to that of other illnesses or diseases.

Yeast infections can be caused by numerous things including having a weakened immune system, being diabetic, taking antibiotics, eating a poor diet full of carbohydrates and sugary foods, and poor hygiene.

Genital Yeast Infection

The most common type of yeast infection that we hear about the most is a vaginal yeast infection in women. A vaginal yeast infection can occur for the same reasons as listed above, along with being on birth control or being pregnant. If you suspect that you have a vaginal yeast infection, you should look for the following symptoms:

  • Burning/itching sensation around the vaginal area
  • A white thick discharge that may sometimes resemble that of cottage cheese
  • Burning during urination
  • Pain during sexual intercourse

These symptoms can be treated with homemade natural remedies and/or over the counter topical creams and ointments. The symptoms may disappear with treatment, however if an underlying cause is behind the yeast infection, that will need to be addressed as well. Seventy five percent of women will experience a yeast infection some time within their life.

A man can develop the same type of yeast infection in his genital area. He may experience the same type of symptoms as a woman, along with red spots located around the head of the penis. Males are a lot less likely to develop this type of yeast infection, but it is possible.

Oral Thrush

Oral thrush is a type of yeast infection that develops inside of the mouth. People that wear dentures or smoke are more susceptible to develop oral thrush than those who don’t. This problem can be very painful and can even cause problems with eating and drinking. Symptoms of oral thrush include: white lesions or patches on the tongue or inside of the cheeks that may become painful and even bleed, a thick coating covering the top of the tongue, loss of taste, and cracking red skin in the corners of the mouth. If oral thrush is not treated properly, it may spread to the throat and esophagus causing more severe problems.

Systemic Yeast Infection

Systemic candidiasis is when a yeast infection enters into the blood stream. This type of infection is typically found in people suffering from A.I.D.S. or Cancer. When this happens, the infection can spread to other organs, including the brain and can even be fatal. Symptoms of systemic candidiasis can include a fever, decreased blood pressure, an increase in heart rate, multi-organ failure, and meningitis. This is the most serious type of yeast infection and needs to be treated immediately.

Nail fungus

A yeast infection can make an appearance on both your fingernails and toenails. When this happens, the nails will typically turn to either a yellow or green color and possible loss of the nail all together. This type of infection may be difficult to diagnose due to the small amount of symptoms that may be present. Many over the counter fungal medications are available for use on the nails, however this type of yeast infection can sometimes be more difficult to treat and may require a stronger prescription medication to get rid of the infection.

Intestinal Yeast Infection

A yeast infection can form easily on the inside of the intestines. This is typically caused by a poor diet. When a person consumes a diet that is high in sugars and carbohydrates, the yeast will feed on them, causing yeast growth. An intestinal yeast infection can exhibit a variety of symptoms, however these symptoms are synonymous with other gastrointestinal problems, making it difficult to diagnose.

Some of the symptoms of intestinal yeast growth may include:

  • Diarrhea
  • Increased gas
  • Unexplained weight loss
  • Migraines
  • Depression
  • Overall discomfort

In order for an intestinal yeast infection to be properly diagnosed, a doctor may need to run some tests before treatment can begin. These tests may include a blood test or a fecal matter test. This type of infection can be difficult to diagnose even for a physician.

Skin Infection

The Candida fungus is present all over the skin making it possible for yeast growth to occur in areas where there is an increase in moisture and heat, especially in the arm pits, groin area, and skin folds. If these areas are not kept clean and dry, a yeast infection may occur causing symptoms inclusive of a red rash, an itching sensation, and burning.

This type of infection can be prevented by keeping these areas clean and dry at all times. Obese people are especially susceptible to getting these types of yeast infections. Over the counter powders, creams and sprays are available to treat these types of candida infections. If a yeast infection occurs frequently, a prescription medication may be needed.

It is always important to take note of what symptoms you are experiencing. If you believe that you have a yeast infection, there are numerous natural remedies and over the counter remedies that you can try. If these fail to rid your body of the infection, medical help should be sought to get stronger treatment. If symptoms persist of get worse, you should see your doctor to ensure that the problem is not something more serious. Yeast infections are very common among people of all age, especially those who have a weakened immune system.

Embarrassment should not be a reason to avoid seeing a doctor if you believe that you have a yeast infection that will not go away with basic treatment, and failure to undergo the appropriate treatment may lead to aggravated health conditions.

Hive

Fungal super-infections turn killer in burns cases

Fungal super-infections turn killer in burns cases

Jan 2012

NEW DELHI: Fungal infections have been found to be a significant cause of death in burns cases, a new study has revealed. Ironically, these infections result from the use of powerful third-generation antibiotics that destroy all bacteria while allowing fungi present in the environment and the gastrointestinal tract to grow unchecked.

A study by doctors at Safdarjung Hospital, published in the medical journal ‘Burns’, shows 12 out of 100 burn injury patients included in the research had fungal infection. The mortality rate among the infected patients was found to be 66.7%. Most of the patients found positive for fungal infection were on three or more higher antibiotics, given either as a combination or over a period of 10 days. “Of this, the commonest were carbapenems and monobactums followed by Piperacillin and Tazobactum,” states the report. Safdarjung Hospital has the largest dedicated burns unit in Asia with an average of 2000 admissions every year.

One of the lead authors of the study, who did not want to be named, said the ubiquity of fungi in the environment along with the suppression of normal bacteria causes the fungal super-infection in burns. “The broad spectrum antibiotics destroy bacteria which grow on the dead tissues in the wound area. But the fungi, which are present in the system, get a chance to proliferate. They turn pathogenic, leading to infection and even death,” he said. Extreme age groups – children and the elderly – diabetes, inhalation injury, prolonged hospital stay and other risk factors increase the chances of fungal infection in the wound.

Experts say that till a few years ago, the burnt surface was considered to be a suitable site for opportunistic colonization and invasion by bacteria which could be checked by early wound excision and skin grafting and the use of antibiotic therapy. But now, anti-fungal therapy is being mulled in view of the increasing incidence of fungal infection in patients.

A senior doctor said, “A lot of effort has been put into treating life threatening bacterial septicemia in burns but often the bacterial culture is negative yet the patient’s condition deteriorates. Fever, sepsis and even death occur as a consequence. No attention was paid towards the cause of this increasing mortality for a long time. Our investigations suggest that all such patients are usually suffering from fungal infection, and this was confirmed with positive biopsy results. Early closure of wound can be effective in fighting this and decreasing the risk.”

Times of India

Invasive Fungal Infections Among Ventilated HSCT Patients in the ICU

Invasive Fungal Infections Among Ventilated HSCT Patients in the ICU

Invasive fungal infection (IFI) is associated with high morbidity and high mortality in hematopoietic stem cell transplantation (HSCT) patients. Chen-Yiu Hung, of the Department of Thoracic Medicine at Chang Gung Memorial Hospital in Taipei, Taiwan, and colleagues, sought to assess the characteristics and outcomes of HSCT patients with IFIs who are undergoing mechanical ventilation (MV) at a single institution in Taiwan.
 
The researchers  performed an observational retrospective analysis of IFIs in HSCT patients undergoing MV in an intensive care unit (ICU) from 2000 to 2009. The characteristics of these HSCT patients and risk factors related to IFIs were evaluated. The status of discharge, length of ICU stay, date of death and cause of death were also recorded.
 
There were 326 HSCT patients at the Linkou Chang-Gung Memorial Hospital (Taipei, Taiwan) during the study period. Sixty of these patients (18 percent) were transferred to the ICU and placed on mechanical ventilators. A total of 20 of these 60 patients (33 percent) had IFIs. Multivariate analysis indicated that independent risk factors for IFI were admission to an ICU more than 40 days after HSCT, graft versus host disease (GVHD), and high dose corticosteroid (p < 0.01 for all). The overall ICU mortality rate was 88 percent (53 of 60 patients), and was not significantly different for patients with IFIs (85 percent) and those without IFIs (90 percent, p = 0.676).

The researchers concluded that there was a high incidence of IFIs in HSCT patients requiring MV in the ICU in their study cohort. The independent risk factors for IFI are ICU admission more than 40 days after HSCT, GVHD, and use of high-dose corticosteroid. Their research was published in BMC Infectious Diseases.

Reference: Hung C-Y, et al. Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit. BMC Infectious Diseases 2012, 12:44 doi:10.1186/1471-2334-12-44

 Infection Control Today

Salon trip could lead to fungal infection

Salon trip could lead to fungal infection

Feb 23, 2012

COLLIER COUNTY, FL –

You could end up in your doctor’s office with a fungal infection after getting a pedicure if your salon doesn’t clean its instruments properly.

Vera Occhipinti gets a pedicure every other month. This time when the dark red nail polish came off, her podiatrist found something she never expected.

“A slight fungus under the dark nail polish,” said Occhipinti.

While Occhipinti has no idea how she got the fungus, she says it easily could have come from her nail salon.

Dr Elena Cibula says Occhipinti is not alone.

The podiatrist has treated several patients with fungal and bacterial infections that came from dirty salon instruments like nail clippers, whirlpools, even the brush of the nail polish.

“If they use instrument one person that had fungus infection and do not disinfect it, it can spread,” said Cibula.

Under state law salons must follow strict guidelines when it comes to cleaning instruments.

Sheila Greer at Polished Nail Boutique says she sanitizes everything to keep anything from spreading.

NBC2 found dozens of inspection reports for salons in Lee and Collier counties that failed to comply with proper cleaning procedures.

We checked out one of those salons, Bohemia Beauty Salon in Naples. According to the report, there was no cleaning solution at all.

The owner didn’t want to go on camera, but says since the inspection they have hired a new nail technician who cleans everything between clients.

If you want to make sure your feet stay fungus-free you should always bring your own tools to the salon. You can also bring your own nail polish. Some places will even give you a discount.

Occhipinti will have to get pricey treatment to get rid of her fungus and make sure it doesn’t spread.

She says now she’ll think twice before getting her nails done.

NBC2

February 25, 2012

Several Conditions Mimic Nail Fungus in Children

Several Conditions Mimic Nail Fungus in Children

Feb 2012

By: JEFFREY EISENBERG, Family Practice News Digital Network

As a pediatric dermatologist, Dr. Robert A. Silverman is all too familiar with this scenario: A child is referred to him with a diagnosis of nail fungus, and the parents are frustrated that the oral antifungal agents did not work.

What bothers him the most is not the antifungals, but that the patients didn’t need them to begin with because the child didn’t have a fungal infection, he said at the annual Hawaii Dermatology Seminar, sponsored by Skin Disease Education Foundation (SDEF). Several conditions of the nail in children can easily be mistaken for fungal infections.

Dr. Silverman of the department of pediatrics at Georgetown University Medical Center in Washington discussed how to distinguish fungal disease mimics from other pediatric nail conditions in children.

Onychomycosis, the most common nail infection in adults, is not all that common in children, Dr. Silverman said. Studies have shown the prevalence in children to be less than 3% in developed countries, although it is increased among children who have Down syndrome and HIV, or children from households with moccasintype Trichophyton rubrum. Clinical variants are similar to those that occur in adults, such as white superficial onychomycosis, distal lateral subungual onychomycosis, proximal subungual onychomycosis, and endonyx onychomycosis.

Other conditions that may be mistaken for fungal infections include:

• Psoriasis. Nail findings in patients who have psoriasis can be misinterpreted as fungal disease. Telltale signs of psoriasis in the nails, however, are large, irregular pits and the oil spot sign.

• Subungual tumors. These include subungual exostosis and onychomatricoma. These benign growths push on the skin surface, leading to separation of the nail. “Some people think fungus when it’s really a tumor of the underlying bone,” Dr. Silverman said.

• Pachyonychia congenitaThough often confused with fungal disease, this condition, which involves a single thickened toenail, is somewhat rare. “If someone came in with a thick toenail, I’d culture him or her,” Dr. Silverman said. “If the culture is negative, then you have to start thinking of these other conditions.”

• Alopecia areata. Children may have nail signs of alopecia areata before hair loss occurs. In alopecia areata, the nail surface is studded to near confluence with tiny pits, also known as Scotch plaid nails. Also, the nail will have lost its luster and has a sandpaperlike texture.

“If you see what looks like alopecia areata of the nail, but don’t see any hair findings, you ought to scrape the nail to rule out fungus, because fungus can look like alopecia areata of the nails,” Dr. Silverman said. “And, of course, then you would want to treat it.”

Treatment for fungal infections requires the use of an oral agent for 6-12 weeks, so Dr. Silverman emphasized the importance of obtaining a culture. “If you’re going to treat someone for that length of time, it makes sense to know exactly what you’re treating,” he said.

Also, Dr. Silverman said, any time he sees that a child’s parent appears to have a fungal infection, he considers that to be a red flag when trying to diagnose the patient.

Family

 

Sensing of mammalian IL-17A regulates fungal adaptation and virulence.

Sensing of mammalian IL-17A regulates fungal adaptation and virulence.

Feb 2012

Zelante TIannitti RGDe Luca AArroyo JBlanco NServillo GSanglard DReichard UPalmer GELatgè JPPuccetti PRomani L.

Source

Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06122, Italy.

Abstract

Infections by opportunistic fungi have traditionally been viewed as the gross result of a pathogenic automatism, which makes a weakened host more vulnerable to microbial insults. However, fungal sensing of a host’s immune environment might render this process more elaborate than previously appreciated. Here we show that interleukin (IL)-17A binds fungalcells, thus tackling both sides of the host-pathogen interaction in experimental settings of host colonization and/or chronic infection. Global transcriptional profiling reveals that IL-17A induces artificial nutrient starvation conditions in Candida albicans, resulting in a downregulation of the target of rapamycin signalling pathway and in an increase in autophagic responses and intracellular cAMP. The augmented adhesion and filamentous growth, also observed with Aspergillus fumigatus, eventually translates into enhanced biofilm formation and resistance to local antifungal defenses. This might exemplify a mechanism whereby fungi have evolved a means of sensing host immunity to ensure their own persistence in an immunologically dynamic environment.

Nature

Invasive fungal disease in PICU: epidemiology and risk factors.

Invasive fungal disease in PICU: epidemiology and risk factors.

Feb 2012

Brissaud OGuichoux JHarambat JTandonnet OZaoutis T.

Abstract

 Candida and Aspergillus spp. are the most common agents responsible for invasive fungal infections in children. They are associated with a high mortality and morbidity rate as well as high health care costs. An important increase in their incidence has been observed over the past two decades. In infants and children, invasive candidiasis is five times more frequent than invasive aspergillosis. Candida sp. represents the third most common agent found in healthcare-associated bloodstream infections in children. Invasive aspergillosis is more often associated with haematological malignancies and solid tumours. Recommendations concerning prophylactic treatment for invasive aspergillosis have been recently published by the Infectious Diseases Society of America. Candida albicans is the main Candida sp. associated with invasive candidiasis in children, even if a strong trend towards the emergence of Candida non-albicans has been observed. The epidemiology and the risk factors for invasive fungal infections are quite different if considering previously healthy children hospitalized in the pediatric intensive care unit, or children with a malignancy or a severe haematological disease (leukemia). In children, the mortality rate for invasive asp

Annals of Intensive Care

 

February 13, 2012

Shedding natural light on fungal infections.

Shedding natural light on fungal infections.

Vecchiarelli Ad’Enfert C.

Source

Department of Experimental Medicine and Biochemical Science; Microbiology Section; Perugia, Italy.

Abstract

Bioluminescence imaging allows the visualization of the temporal and spatial progression of biological phenomena, in particular infection, by non-invasive methods in vivo. This nature-borrowed technology has been successfully used to monitor bacterial infections but recent studies have also succeeded in tracking fungal infections such as those caused by the two major opportunistic fungal pathogens Candida albicans and Aspergillus fumigatus. The findings of Donat and collaborators published in this issue now show that by combining the sensitivity of the Gaussia princeps luciferase with a surface display expression system it is possible to perform longitudinal infection studies on cutaneous forms of aspergillosis with a small number of animals. Besides providing new and valuable information in the field of aspergillosis, the findings of Donat et al. offer a new perspective on the general applicability of bioluminescence methodologies for eukaryotic pathogens where the bacterial lux operon cannot be exploited.

Landis Bioscience

Triple fungal infection in a patient with liver cirrhosis.

Triple fungal infection in a patient with liver cirrhosis.

Feb 2012

Alidjinou KMathieu DColombel JFFrançois NPoulain DSendid B.

Source

Laboratoire de parasitologie-mycologie, Institut de microbiologie, Centre de biologie pathologie.

Abstract

Keywords : triple fungal infection, Candida albicans, Aspergillus fumigatus, Pneumocystis jirovecci, liver cirrhosis

The prevalence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections are associated with a high morbidity and significant mortality, requiring early diagnosis and appropriate treatment but also an optimal prophylaxis in patients with high risk factors. We report a case of triple fungal infection including an invasive pulmonary aspergillosis by Aspergillus fumigatus, a candidemia by Candida albicans and a Pneumocystis pneumonia. The overall clinical picture of this patient was liver cirrhosis with medical history of immunosuppressive treatment for Crohn disease and a non-hodgkin lymphoma. There was no antifungal prophylaxis for this patient. Under treatment, the issue was unfavourable with multivisceral failure.

John Libbey Eurotext

Photodynamic Antifungal Chemotherapy

Photodynamic Antifungal Chemotherapy

Feb 2012

Piergiacomo CPTeresa RMRaffaella SMarina V.

Source

Department of Dermatology, University of Brescia, Brescia, Italy.

Abstract

The growing resistance against antifungal drugs has renewed the search for alternative treatment modalities, and antimicrobial photodynamic therapy (PDT) seems to be a potential candidate. Preliminary findings have demonstrated that dermatophytes and yeasts can be effectively sensitized in vitro and in vivo by administering photosensitizers (PSs) belonging to four chemical groups: phenothiazine dyes, porphyrins and phthalocyanines, as well as aminolevulinic acid, which, while not a PS in itself, is effectively metabolized into protoporphyrin IX. Besides efficacy, PDT has shown other benefits. First, the sensitizers used are highly selective, i.e., fungi can be killed at combinations of drug and light doses much lower than that needed for a similar effect on keratinocytes. Second, all investigated PSs lack genotoxic and mutagenic activity. Finally, the hazard of selection of drug resistant fungal strains has been rarely reported. We reviews the studies published to date on antifungal applications of PDT, with special focus on yeast, and aims to raise awareness of this area of research, which has the potential to make a significant impact in future treatment of fungal infections. 

PubMed

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