Fungal Infections

February 25, 2012

Invasive fungal disease in PICU: epidemiology and risk factors.

Invasive fungal disease in PICU: epidemiology and risk factors.

Feb 2012

Brissaud OGuichoux JHarambat JTandonnet OZaoutis T.


 Candida and Aspergillus spp. are the most common agents responsible for invasive fungal infections in children. They are associated with a high mortality and morbidity rate as well as high health care costs. An important increase in their incidence has been observed over the past two decades. In infants and children, invasive candidiasis is five times more frequent than invasive aspergillosis. Candida sp. represents the third most common agent found in healthcare-associated bloodstream infections in children. Invasive aspergillosis is more often associated with haematological malignancies and solid tumours. Recommendations concerning prophylactic treatment for invasive aspergillosis have been recently published by the Infectious Diseases Society of America. Candida albicans is the main Candida sp. associated with invasive candidiasis in children, even if a strong trend towards the emergence of Candida non-albicans has been observed. The epidemiology and the risk factors for invasive fungal infections are quite different if considering previously healthy children hospitalized in the pediatric intensive care unit, or children with a malignancy or a severe haematological disease (leukemia). In children, the mortality rate for invasive asp

Annals of Intensive Care



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