Fungal Infections

September 25, 2009

Zygomycosis and diabetes mellitus.

Zygomycosis and diabetes mellitus.

Clin Microbiol Infect. 2009 Oct;15

Lanternier F, Lortholary O.

Université Paris Descartes, Centre d’Infectiologie Necker-Pasteur, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants malades, Paris, France.

Zygomycoses are severe angio-invasive fungal infections that develop in immunocompromised and diabetic patients. Any episode of sinusitis not responding to short-term antibacterial therapy should evoke the diagnosis of zygomycosis in the latter population, especially in cases of a surrounding necrotic area. Appropriate diagnosis is obtained after careful direct examination of the sample and culture. Current therapy underscores the need to control glycaemia and acidosis in addition for urgent administration of high-dose liposomal amphotericin B in combination with extensive surgery.


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